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In the over 2500 participants, who were assigned to the 5, 10, and 15 mg doses of tirzepatide and placebo, the percent weight changes were both statistically and clinically significant compared with placebo

Research shows that around two-thirds of people regain weight within a year of stopping semaglutide without ongoing behavioural support

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Clinicians should recognize that patients undergoing polypharmacy require heightened vigilance, comprehensive monitoring, and specialized counseling