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The nausea usually peaks 1-3 days after injection and gradually diminishes as your body adapts over 2-4 weeks

Wegovy is licensed in the UK in doses up to 2.4mg for weight loss and, on 14 September 2025, Novo Nordisk published results of a phase IIIb clinical trial (STEP UP, NCT05646706) of a 7.2mg dose of semaglutide for subcutaneous injection 1

Use this tool as a rough guide to what you can expect, rather than a fixed schedule, since the experience varies from person to person

Diabetic neuropathy benefits Perhaps most relevant to the semaglutide discussion, research demonstrates that GLP-1 receptor agonists can ameliorate diabetic neuropathic pain by inhibiting neuroinflammation in the spinal cord

It is also advised to avoid mega doses of pyridoxine in pregnant or breastfeeding patients unless necessary, since safety data for doses beyond the recommended dietary allowance are limited