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Researchers should understand both the available data and its limitations

References Heffernan MA, Jiang WJ, Thorburn AW, Ng FM

Shifting neurochemistry can be stressful

Patients with pancreatic insufficiency may have reduced cobalamin absorption (because pancreatic enzymes normally assist with the displacement of salivary haptocorrin binding protein by intrinsic factor), although such patients rarely become cobalamin deficient

The zero withdrawal rate in AOD-9604 trials suggests excellent practical tolerability that extends beyond merely counting adverse events to assessing their real impact on treatment continuation