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The observed reduction in seminiferous tubule diameter in the PRP/PC group can be interpreted in the context of ongoing tissue remodeling, where residual degenerative changes and early fibrotic processes may contribute to tubular compaction
Vascular endothelial cells demonstrate functional GLP-1 receptors, providing a direct mechanism for the vasodilatory effects observed with GLP-1 agonists [3]
Conclusions Evidence accrued so far suggest that GLP-1RA could exert a modest renal benefit alongside CV protection, justifying its place as second-line drug in patients with T2D and CKD not achieving glycemic control with SGLT-2i and metformin according to KDIGO guidelines [87]