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Preclinical studies have demonstrated that Epithalon activates telomerase in somatic cells through activation of telomerase reverse transcriptase, which promotes telomere elongation, and delays cellular senescence

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1B), we further performed particle subtraction on this domain to improve the resolution to 2.65 , and the resulted reconstruction enabled the fitting of the individual atomic models for DDB1, DDA1 (PDB: 6DSZ) and DET1 (AlphaFold model: AF-Q7L5Y6-F1), allowing for the modelling of most of the complex 34

Oxygen and glucose deprivation (OGD) model and cell viability To imitate the in vivo environment of ischemia and hypoxia after fat transplantation, ADSCs were cultured under hypoxic and glucose-free conditions to induce an OGD model

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