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Semaglutide reduces appetite immediately, but the scale lags behind by 12 weeks because early weight changes are mostly water loss and metabolic adjustment

Extra caution is important with: Frequent vomiting or suspected cannabinoid hyperemesis Symptoms of gastroparesis, including early fullness, nausea, vomiting, bloating, and upper abdominal pain Diabetes medications that can cause low blood sugar, including insulin or sulfonylureas Heavy cannabis use, high THC products, or unpredictable edibles dosing Prior dehydration, severe constipation, pancreatitis, or unexplained severe abdominal pain Very low appetite, unintended weight loss, or eating disorder history Multiple sedating substances Upcoming surgery, anesthesia, endoscopy, colonoscopy, or gastric emptying testing GLP-1 medications can delay gastric emptying, which also matters for procedures and anesthesia planning

As with any medication, individual responses vary, and those with specific contraindications should not use it

A normal diet meal might rely on a large salad, a big grain bowl, or a giant portion of lean meat

Why Physical Therapy Matters At Bethesda Physiocare, we specialize in creating targeted strength training programs that help preserve lean muscle and promote healthy musculoskeletal adaptation during weight loss