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When used long-term (52 weeks), nausea (40%) was the only severe adverse event noted in a study of 272 female patients taking PT-141

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HTRA2 defect: a recognizable inborn error of metabolism with 3-methylglutaconic aciduria as discriminating feature characterized by neonatal movement disorder and epilepsy-report of 11 patients

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Body Composition Findings Data suggests weight reduction is largely derived from fat mass, with comparatively limited lean muscle loss