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We now understand obesity in a way that we didnt 10 or 20 years ago, and we know obesity is a metabolic disease
Whilst there is movement to design cannabanoid-1 receptor antagonists that are less hydrophobic to reduce blood-brain barrier penetration and therefore psychiatric side effects [105], we are not aware of any ongoing clinical trials yet
These side effects can be disruptive, affecting daily activities and adherence to treatment
Desmopressin is poorly transferred into human breastmilk at negligible amounts (see Data)
Patient preference and experience should guide final selection
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