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Whilst evidence from clinical trials is limited, NAC promises to be effective at increasing heavy metal excretion, with a dose of 800 mg per day sufficient to lower blood levels of lead in exposed workers

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[22] Some of these metabolic improvements may occur partly independently of weight loss, as suggested by mediation analyses from cardiovascular outcome trials, potentially reflecting effects on insulin sensitivity and vascular health that may be relevant for patients with obesity-related comorbidities like sleep apnea

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The odds ratio more than doubled when treatment exceeded 1.5 years (OR 2.32 vs 1.64 overall)