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Notably, key transcription factors such as SOX2, which promote and maintain the dry characteristics of cancer cells, can upregulate the expression and autocrine activity of IGF-2, and IGF-2 then activates the IGF-1R/AKT signaling pathway to enhance the invasive and stemness characteristics of bladder cancer, forming a vicious cycle (28)
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Abstract Introduction The optimal positioning and sequencing of sodium-glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in adults with chronic kidney disease (CKD) with type 2 diabetes (T2D) and overweight/obesity is unclear
Longevity Markers Gene-network studies report modulation of stress-response and proteostasis pathways
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