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(2) preclinical-to-clinical gaps persist in dose optimization (e.g., PK/PD modeling for febuxostatSEDDSs) and delivery route validation (e.g., human skin studies for elastic liposomes), with limited data on patient compliance and real-world applicability

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exactly when women need protection most: Time-Restricted Feeding + Resistance Training : In active women following an eight-week time-restricted feeding protocol (eating only between noon-8pm) combined with resistance training, HMB supplementation at 3 grams daily produced significant improvements in body composition