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BlauJEBaumanVConwayEMPiaggiPWalterMFWrightECet al

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However, compounding cannot resolve: Unknown long-term biological effects Poorly defined dosing Weak evidence of benefit Inadequate interaction data Immunogenicity or peptide-impurity risks Inappropriate patient selection Marketing claims that exceed the evidence The pathway could also create a new problem if pharmacy availability is interpreted as government endorsement

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