Citrulline is a non-essential amino acid that is an important intermediate in the urea cycle, functioning along with other amino acids to rid the body of ammonia, a byproduct of protein metabolism
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The recent meta-analyses indicated that in patients with high TMAO plasma level, the incidence of major adverse cardiovascular events was significantly higher compared with patients with low TMAO levels [67], and that all-cause mortality increased by 7.6% per each 10 mol/L increment of TMAO [68]
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This results in decreased muscle strength, slow growth, and most notably, stubborn fat reserves that may be extremely difficult to remove