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(15) After inducing diabetic osteoporosis through a high fat diet and streptozotocin, light and scanning electron microscopy revealed evidence of bone deterioration via the upregulation of nuclear factor kappa-B ligand (RANKL) and downregulation of pro-osteogenic markers OPG and osteocalcin

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These were generally mild, in the range of 2-4 beats per minute at lower doses and up to 6-8 BPM at 12mg, and did not produce clinical symptoms in most participants

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Washington, DC, American Psychiatric Press, Inc., 2005