Abnormal potassium ion channels may accelerate pathological -Syn accumulation, increasing the risk of PD
However, if you also take insulin or sulfonylureas, NICE recommends regular testing (typically before meals and at bedtime) due to increased hypoglycaemia risk, particularly during dose titration
Overbasalization refers to increasing the basal dose of insulin after the fasting glucose goal has been achieved, in an attempt to lower prandial glucose
doi: 10.1073/pnas.1308421110 79 DonnellyC
[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing