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WELLBUTRIN is contraindicated in patients with known hypersensitivity to bupropion or other ingredients of WELLBUTRIN

This can happen for various reasons, such as when a doctor believes the medication may benefit a particular patient's condition, even though it hasn't been officially tested and approved for that specific use

Topical numbing can be applied to the injection site

At the molecular level, central or peripheral insulin resistance can result from reduced insulin receptor expression, decreased binding affinity, and disruption of downstream signaling pathways (Tatar et al., 2003)

I have not been able to do this with heavy exercise or dieting