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Both Concerta and Adderall XR offer roughly 10, 12 hours of symptom coverage with once-daily dosing, while Adderall IR lasts only 4, 6 hours and requires multiple doses throughout the day for all-day relief

No hepatotoxicity, no cardiovascular signals, no serious adverse events

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At week 36, the 12mg group showed the most dramatic eating behavior changes: Perceived hunger decreased by 2.4 points versus placebo Disinhibition improved by 2.6 points Dietary restraint increased by 3.3 points 100% of participants achieved at least 5% body weight loss by week 48 83% achieved 15% or greater weight loss Mean weight reduction reached 24.2% at 48 weeks These numbers represent the strongest weight loss and appetite-related outcomes ever recorded in clinical trials for any GLP-1 class medication