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The ESC-NAM cocrystal improves water solubility 3fourfold and oral bioavailability 2threefold compared to amorphous ESC
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These inter-agent differences may be due to pharmacokinetic and pharmacodynamic distinctions including receptor internalization rates and secondary messenger activation 38
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Even determining which form of the drug should be used was unclear to regulators, since BPC-157 is not recognized as an official pharmaceutical ingredient in the U.S
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