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To confirm the potential functions of the 13 putative GhGPXs, we analysed the homology between GhGPX and AtGPX protein sequences using WU-BLAST2 ( Using the protein sequences of GhGPXs, we found the highest homology of AtGPX to each GhGPX protein (Table 2), for example, the amino acid sequences of GhGPX1 and AtGPX1 had 79% identity, while GhGPX6 and AtGPX6 had 78% identity

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Mitochondrial dysfunction and DNA damage : Dysregulation of the NAD/PARP1/SIRT1 axis and mitochondrial injury promotes fibrogenesis and hepatocyte dysfunction [131, 132]