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This is particularly relevant for oral administration, which is subject to intrinsic factor saturation and receptor limitations in the ileum ( Moreover, our results highlight the essential role of vitamin B12 in homocysteine metabolism, as supplementation was associated with a significant reduction in serum homocysteine levelsan important biomarker associated with cardiovascular and neurodegenerative diseases
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Other conditions common in people with obesity or diabetes can also contribute to fatigue, including sleep apnoea, thyroid disorders, and depression
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Dosing Protocol Suggested weekly titration approach based on clinical trial designs [1] [6]
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