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External Authority Organizations like the American Academy of Orthopaedic Surgeons (AAOS) stress caution with unapproved treatments, urging patients to seek guidance from board-certified specialists

Such drugs can be "extremely dangerous and, in certain situations, deadly," the group says

Pregnancy or breastfeeding: Reviewed case by case

B12 may accelerate red blood cell production in ways that may be harmful in this condition Use during pregnancy or breastfeeding should occur only if a licensed healthcare provider determines that potential benefits outweigh potential risks

Both compounds push cellular signaling toward reduced oxidative stress and lower inflammatory tone