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Also in 2002, a GIP analogue with an N-terminal substitution of glutamic acid in position 3 with proline (Pro3), was made as an attempt to prolong the GIP actions by protecting from DPP-4 degradation (66) ( Figure 1 )

Breaks allow receptor populations to recover and resensitize

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Kent Berridge, professor of psychology and neuroscience at the University of Michigan, has noted that GLP-1 drugs may lower the "wanting" component of pleasure -- the motivational drive toward rewarding experiences -- even if the capacity for "liking" remains intact

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