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For both males and females, over 90% of test results fell within the established reference intervals, demonstrating that the intervals determined in this study are appropriate for clinical use (Table IV)

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Vital Signs and Electrocardiograms With the combination of sitagliptin and metformin immediate-release, no clinically meaningful changes in vital signs or in electrocardiogram parameters (including the QTc interval) were observed

However, the timing of supplementation is critical to maximizing its benefits

Food and Drug Administration , Accessed 31 Mar