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Keep supplemental magnesium at or under the 350 mg/day upper limit (NIH Office of Dietary Supplements) and vitamin D at or under 4,000 IU/day (NIH Office of Dietary Supplements) unless a prescriber directs otherwise

Taken together, these pharmacokinetic findings indicate that the centrally mediated effects of GLP-1RAs are likely due to limited brain penetration or action at sites adjacent to the BBB, rather than widespread distribution throughout the central nervous system

It may also increase the bioactivity of certain antibiotics

Factors such as previous eye problems, cardiovascular disease, and use of other medications known to increase NAION risk (like PDE5 inhibitors) should be carefully evaluated before starting GLP-1 therapy