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Kennedy concludes, microdosing GLP-1s can be a practical, cost-effective alternative for patients who either cant tolerate full doses or are looking for a gentler on-ramp to treatment

Starting at a lower dose allows tissues to respond without overstimulation, then the higher dose in Phase 2 extends and deepens that response

While current human observational data provide reassuring safety profiles and highlight metabolic advantages, true evidence for intrinsic disease modification remains limited and heavily confounded by systemic weight loss

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