Side Effects at Higher Doses GLP-1 receptor agonists may cause gastrointestinal symptoms such as: Nausea Vomiting Diarrhea Constipation Decreased appetite These effects are often more common as doses increase
Furthermore, an in vivo efficacy study in a diabetic mouse model showcased the robust performance of the oral capsule formulations containing sEV-semaglutide and sEV-tirzepatide
Notably, in the condition of excess hemin exposure and hypoxia, our findings suggest an important contribution of the TSS pathway and its regulation by DMF for de novo cysteine synthesis and GSH generation in protecting against the oxidative and ferroptotic stresses in SCD erythroblasts
The second most common side effect reported are reactions at the injection site, such as redness, swelling and itching 19
(PubMed) Xu Y, Jiang W, Chen G, et al