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Lancet Diabetes Endocrinol 2021;9:743-54.ArticlePubMed 59
Milder adverse effects and other reasons for treatment discontinuation were also likely underestimated because registry data cannot fully capture them
In the STEP 1 trial, the 2.4 mg dose led to an average weight loss of 14.9% over 68 weeks
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It is noted that, whether in vitro or in vivo experiments, the combination of harmine and Ex-4 can significantly promote the proliferation of human -cells compared with harmine alone, which may also be related to the promotion of trans-differentiation from -cells to -cells [44]
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