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it avoids meaningful prolactin and cortisol elevation at doses studied, making it the lower-hormonal-spillover option
11 However, human data remains largely inconclusive, necessitating additional research to establish efficacy and optimal dosage
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One notable difference is that tirzepatide is a dual-agonist (GLP-1 and GIP) while retatrutide is a triple-agonist (GLP-1, GIP, and glucagon)
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