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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

If fatigue is severe, persistent or interfering with daily life, its important to speak with a healthcare provider

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However, stress, pollution, smoking, toxins, poor diet, inflammation, and ageing can increase their production