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Additionally, it has received accelerated approval for treating noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver fibrosis
Clinical Importance: Oral semaglutide is the first oral GLP-1 receptor agonist, combining meaningful HbA1c reduction, clinically relevant weight loss, and favorable blood-pressure effects in a once-daily tablet
Participants also showed reduced waist circumference, blood pressure, fasting blood glucose, and insulin levels, along with nearly complete elimination of liver fat in a prior MASLD substudy
This process uses up a lot of potassium