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The prevalence of HFpEF is rising, increasing from 33 to 39% between 2005 and 2010, with projections suggesting it will soon become the most common form of HF [5, 6]

For women with known PCOS or other reproductive endocrine conditions, baseline and follow-up assessments of metabolic and reproductive parameters can help distinguish medication effects from underlying disease progression

The increase in ROS levels activates the transcriptional factor NF-B, leading transactivation of the viral genes and inducing the transcription of viral proteins [12]

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Preclinical studies demonstrated that AOD-9604 was generally safe after chronic oral application in rats and cynomolgus monkeys, with no genotoxic concerns identified