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GSH acts as an inhibitor of extended inflammation directing components of innate immunity like polymorphonuclear neutrophils specifically to the site of infection/damage allowing a proper response to infection
van Rumund A, Green AJE, Fairfoul G, Esselink RAJ, Bloem BR, Verbeek MM
therefore GSH/GSSG ratio is critical indicator of the health of cell
We can enhance the anti-tumour capacities of neutrophils by interfering with innate immune inhibitory checkpoints to restore antibody-mediated anti-tumour activities, by targeting proteins downstream of the inhibitory receptor, by using IgA-based therapeutic mAbs that bind to the activating Fc receptors, and by modifying the Fc region of IgG therapeutic antibodies that increases affinity to Fc receptors, as shown in Figure 6 (53)
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