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Additionally, rapid weight loss can alter electrolyte balance, with potential effects on neuromuscular function
However, in keeping with our data on receptor pharmacology, increasing the dose to 30 nmol kg 1 , tenfold higher than maximal doses from our studies, shows that tirzepatide does have insulinotropic activity in Glp1r -/- mice or in the presence of a GLP-1R antagonist 5 , demonstrating that tirzepatide can engage the GIPR in mouse beta cells at sufficiently high concentrations
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Add to that ANY interplay of Gaba,Acetycholine, BDNF et al
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