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Co-Primary Analysis The active comparator analysis comparing dual therapy versus GLP-1 RA monotherapy (N = 13,782 matched pairs) demonstrated that dual therapy was associated with lower colon cancer risk compared with GLP-1 RA monotherapy alone (115 events [0.8%] vs 179 events [1.3%]

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Directly, GLP-1 RAs may lower inflammatory cytokine production, blunt Toll-like receptormediated responses to bacterial stimuli, and promote tissue repair by reducing matrix metalloproteinases, offering a plausible immunomodulatory benefit beyond weight change alone