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A landmark study published in PNAS demonstrated that Akkermansia muciniphila interacts directly with the intestinal epithelium and that, in animal models, administering this bacterium reversed key markers of diet-induced obesity, including fat mass gain, metabolic inflammation, and gut barrier disruption
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Beyond modest lipid improvements, GLP-1 receptor agonists have demonstrated substantial cardiovascular benefits in large-scale outcome trials, establishing them as important cardioprotective agents for appropriate patients
PI3K/Akt/mTOR + MAPK/ERK Activates both the metabolic (PI3K/Akt/mTOR - protein synthesis, glucose uptake) and proliferative (MAPK/ERK) IGF-1 signalling cascades
Losing weight can help lower this inflammation, but the way weight is lost makes a difference
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