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Strategy #2 (reduction of RCS/AGE levels) Under normal conditions, the multilevel and complex antiglycation system is effective enough at both preventing the formation (Figure 5, red arrows 4, 5 and 6) and reducing the amount of reactive carbonyls and AGEs (Figure 5, red arrows 5 and 6)

Para to ortho repositioning of the arsenical moiety of the angiogenesis inhibitor 4-( N -( S -glutathionylacetyl)amino)phenylarsenoxide results in a markedly increased cellular accumulation and antiproliferative activity

Further, it suggested that downregulation of HER-2/neu gene expression might be responsible for the anticancer activity of this peptide[5, 6]

Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, et al