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This meta-analysis of all CVOTs conducted with oral and parenteral semaglutide to date revealed that the use of semaglutide as a molecule resulted in a significant 21% reduction in MACE, which was driven by reduction in CV death (HR 0.79, 95% CI 0.610.90)
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Doing so increases the risk of exposure to harmful conditions and makes it harder to track expiration dates or identify formulation types
Cautions include patients with a history of pancreatitis or severe gastrointestinal disease
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