olympia semaglutide vial OR COMPOUNDED? : r/glp1 Remove Cap from Olympia Bottle

In clinical trials, semaglutide has demonstrated superior weight loss compared to older GLP-1 analogs, with an average loss of 15-20% of body weight

REDEFINE 2 Trial Type 2 Diabetes with Obesity The companion REDEFINE 2 trial, also published in 2025, enrolled 1,206 adults with type 2 diabetes and obesity or overweight, demonstrating the combinations efficacy in this more metabolically compromised population: Mean weight loss of 13.7% compared to 3.4% with placebo over 68 weeks 73.5% achieved hemoglobin A1c of 6.5% or less compared to 15.9% with placebo Greater proportions reaching multiple weight thresholds including 5%, 10%, 15%, and 20% reduction Significant glycemic improvement with mean A1c reduction demonstrating disease modification potential Favorable metabolic profile changes including improvements in blood pressure and lipids These findings established that the combination maintains substantial efficacy even in patients with the metabolic dysfunction of established type 2 diabetes, a population often showing reduced response to weight-loss interventions

Endocrinology 2023, 164(5)

Everything on this page is educational research context

Our ambition with this app is to raise the standard of day-to-day support as more people use GLP-1s as a part of their weight loss journey