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Individuals who may benefit from Vitamin B supplements include those with dietary restrictions (like vegans, who might lack vitamin B12), the elderly, those with certain medical conditions, pregnant women (who may need more Vitamin B9), and anyone with a diagnosed deficiency in one or more Vitamin B nutrients

Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, making this finding especially relevant for clinical application

Most of what we know is preclinical, and real-world human trials are not yet strong

While their mechanisms may differ, their combination has been proposed to provide complementary or synergistic actions

They are vitamin B6 and vitamin B12