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Dose escalation speed is another factor

Cigna said it would continue supporting workers through weight-management programs and other resources, but the core decision is clear enough: the company no longer wants its plan paying for GLP-1s when they are prescribed for weight loss

Acknowledgements This work was funded by Novo Nordisk

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Moreover, with the maximum oral dosage plasma levels are lower compared with the maximal subcutaneous dose (oral 20 mg yields plasma levels of ~25 nM, subcutaneous 1 mg yields plasma levels of ~45 nM ( Table 2 )