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Semaglutide-related fatigue primarily occurs due to dramatically reduced calorie intake as appetite suppresses, rapid weight loss causing metabolic adjustments, possible dehydration from eating and drinking less, inadequate protein consumption leading to muscle loss, blood sugar changes particularly in people with diabetes, and possible sleep disruptions

In addition, catabolic genes Atrogin-1 and MuRF-1 were also not changed by the supplementation (data not shown)

The distinction between ingredient-level findings and product-level clinical proof applies here as it does across the broader supplement category