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2019;26(6):1399-1408.e6

GLP-1 receptor sensitivity varies among individuals due to genetic variation and baseline metabolic state

In the presence of differentiation stimuli, abnormal protein folding in the ER activates the unfolded protein response (UPR) signaling, which can be alleviated by global translational attenuation, induction of molecular chaperones, misfolded protein degradation by endoplasmic reticulum-associated degradation (ERAD), and apoptosis (63)

If convenience is the main concern, both formats have practical merits

This assessment should include a detailed history of symptom onset, frequency, severity, and relationship to medication initiation or dose changes