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In vitro studies have utilized human umbilical vein endothelial cells (HUVECs) to investigate angiogenic activity, human fibroblast cultures for wound migration assays, and tendon fibroblast primary cultures to examine collagen synthesis rates
Some studies explore nitric oxide signaling, fibroblast migration, collagen organization, endothelial function, and tissue repair processes
The results: if there is an excess of vitamin B12 in the skin, the gene activity of these skin bacteria changes and they produce more of a molecule that fuels inflammatory processes
D., Dimaio, J
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