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Todays decision by the FDA reflects the continued progress in how we understand and treat patients with MASH, bringing us closer to care that meets the needs of people living with this disease, said Arun Sanyal, MD, director of the Stravitz-Sanyal Institute for Liver Disease and Metabolic Health at Virginia Commonwealth University

First, since our study is an exploratory study, we calculated group sample sizes according to the effects of SGLT-2i and GLP-1 RA monotherapy on NASH rather than the effect of combination therapy

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Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor