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It has been found that treating RPE cells with high-concentration glucose solution (30 mM) increases ROS levels, promotes cell ferroptosis, and inhibits cell proliferation and vitality in RPE

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In an effort to identify NRF2 structural domains responsive to oxidative stress and electrophilic compounds, such as sulforaphane, researchers uncovered a novel regulator of NRF2 (Itoh et al., 1999)