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While this is still well below untreated levels, the 2018 AHA/ACC cholesterol guideline emphasizes sustained LDL-C lowering for maximum atherosclerotic plaque regression [8]

Supporting Evidence A 2025 systematic review and meta-analysis of nearly 29,000 patients across observational studies and randomized trials found tirzepatide produced significantly greater weight reduction than semaglutide, with notably higher odds of achieving at least 10% weight loss

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S., Pereira, E

These include (in no particular order): Nausea Vomiting Diarrhea Constipation Stomach pain Loss of appetite Headache Dizziness Fatigue Injection site reactions (such as redness, swelling, or itching) Less common but more serious side effects of semaglutide may include: Pancreatitis (inflammation of the pancreas) Kidney problems Gallbladder problems Hypoglycemia (low blood sugar) Hypersensitivity reactions (such as rash, hives, or difficulty breathing) The majority of the side effects are short-lived and go away once your body gets used to the medication dosage