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Differential changes in PKLR in males (decreased) and females (increased) could have significant functional consequences in liver since glycolytic inhibition (such as by decreases in PKM2) has been suggested to promote the pentose phosphate pathway to generate higher levels of NADPH
The mechanism of action involves mimicking the effects of two incretin hormones, GLP-1 and GIP, which play crucial roles in insulin secretion and appetite regulation
and receiving research funding from the Department of Veterans Affairs Health Services Research & Development and National Institutes of Health
This makes Zepbound an excellent choice for patients needing more aggressive weight loss or those who havent found success with single-agonist medications
