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In a five-axis world, where each axis has a leading drug optimized for a different dimension, choosing wrong has a meaningful cost (a year on the wrong molecule, a side-effect profile that doesnt fit the patients priorities, an event that wasnt prevented)
Anderson ME, Allison RD, Meister A: Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids
Semaglutide is suitable for individuals with a BMI of 30 or higher or for those with a BMI of 27 or higher who also have weight-related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol
Sci Rep 12:5639
Many people face this same challenge, and the good news is that there's a sustainable way to maintain the benefits of these medications while gradually reducing your dependence on GLP-1 drugs - even if you feel like you'd tried everything before going on the drugs
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