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All participants had HbA1c levels between 7.0% and 9.5% plus a body mass index of at least 23 kg/m2 atbaseline

Because hepatotoxicity is rare after acute overdose, the lack of transaminase elevation following prophylactic carnitine administration does not demonstrate its hepatoprotective properties

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Moreover, Gpx4 has been shown recently to modulate ferroptotic cancer cell death, a specific form of cell death characterized by the production of iron-dependent ROS generation (Yang et al., 2014)

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