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In sum, defective autophagy is associated with the induction of epileptogenesis and the development of epilepsy

Some meta-analyses and commentary have suggested an association between semaglutide and increased DVT risk in certain populations, but these findings are controversial and do not by themselves prove causation especially given confounding factors like underlying metabolic disease and dehydration from gastrointestinal side effects

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In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight - about 25 pounds on average - over more than 16 months